Publications
Scanned optogenetic control of mammalian somatosensory input to map input-specific behavioural outputs.
Ara Schorscher-Petcu, Flora Takacs, Liam E. Browne
eLife (2021) (link)
Epineural optogenetic activation of nociceptors initiates and amplifies inflammation.
Frédéric Michoud, Corey Seehus, Philipp Schönle, Noé Brun, Daniel Taub, Zihe Zhang, Aakanksha Jain, Ivan Furfaro, Outman Akouissi, Rachel Moon, Pascale Meier, Katia Galan, Benjamin Doyle, Michael Tetreault, Sébastien Talbot, Liam E. Browne, Qiuting Huang, Clifford J. Woolf, Stephanie P. Lacour
Nature Biotechnology (2020) (link)
Vagal sensory neurons drive mucous cell metaplasia.
Sebastien Talbot, Benjamin Doyle, Junwei Huang, Jo-Chiao Wang, Maryam Ahmadi, David P. Roberson, Ajay Yekkirala, Simmie L. Foster, Liam E. Browne, Bruce P. Bean, Bruce D. Levy, Clifford J. Woolf
Journal of Allergy and Clinical Immunology 145, 1693-1696.e4 (2020) (link)
Controlling engineered P2X receptors with light.
Benjamin N. Atkinson, Vijay Chudasama, Liam E. Browne
Methods in Molecular Biology (2019) (link)
Optical cuff for optogenetic control of the peripheral nervous system.
Frédéric Michoud, Loic Sottas, Liam E. Browne, Leonie Asboth, Alban Latremoliere, Miyuki Sakuma, Gregoire Courtine, Clifford J. Woolf, Stephanie P. Lacour
Journal of Neural Engineering 15, 015002 (2018) (pdf)
Time-resolved fast mammalian behavior reveals the complexity of protective pain responses.
Liam E. Browne*, Alban Latremoliere, Brendan P. Lehnert, Alyssa Grantham, Catherine Ward, Chloe Alexandre, Michael Costigan, Frédéric Michoud, David P. Roberson, David D. Ginty, Clifford J. Woolf*
Cell Reports 20, 89-98 (2017) *co-corresponding authors (pdf)
Casting light on pain.
Liam E. Browne, Clifford J. Woolf
Nature Biotechnology 32, 240-241 (2014) (link)
Optical control of trimeric P2X receptors and acid-sensing ion channels.
Liam E. Browne, Joao Nunes, Joan A. Sim, Vijay Chudasama, Laricia Bragg, Stephen Caddick, R. Alan North
PNAS 111, 521-526 (2014) (pdf)
Ectodomain movements of ATP-gated ion channel (P2X2 receptor) probed by disulphide locking.
Olga Stelmashenko, Vincent Compan, Liam E. Browne, R. Alan North.
Journal of Biological Chemistry 289, 9909-9917 (2014) (link)
P2X receptor intermediate activation states have altered nucleotide selectivity.
Liam E. Browne, R. Alan North
Journal of Neuroscience 33, 14801-14808 (2013) (pdf)
P2X7 receptor channels allow direct permeation of nanometer-sized dyes.
Liam E. Browne, Vincent Compan, Laricia Bragg, R. Alan North
Journal of Neuroscience 33, 3557-3566 (2013) (pdf)
P2X receptor channels show threefold symmetry in ionic charge selectivity and unitary conductance.
Liam E. Browne, Lishuang Cao, Helen E. Broomhead, Laricia Bragg, William Wilkinson, R. Alan North
Nature Neuroscience 14,17-18 (2011) (pdf) Appears in Faculty of 1000: F1000.com/8819956
Pharmacological properties of the rhesus macaque monkey P2X7 receptor.
Helen J. Bradley, Liam E. Browne, Wei Yang, Lin-Hua Jiang
British Journal of Pharmacology 164(2b), 743-754 (2011)
New structure enlivens interest in P2X receptors.
Liam E. Browne, Lin-Hua Jiang, R. Alan North,
Trends in Pharmacological Sciences 31, 229-237 (2010)
Structural determinants of drugs acting on the Nav1.8 channel.
Liam E. Browne, Frank E. Blaney, Shahnaz P. Yusaf, Jeff J. Clare, Dennis Wray
Journal of Biological Chemistry 284, 10523-10536 (2009)
Functional and pharmacological properties of human and rat Nav1.8 channels.
Liam E. Browne, Jeff J. Clare, Dennis Wray
Neuropharmacology 56, 905-914 (2009)
Photo by Alfons Morales on Unsplash
Ara Schorscher-Petcu, Flora Takacs, Liam E. Browne
eLife (2021) (link)
Epineural optogenetic activation of nociceptors initiates and amplifies inflammation.
Frédéric Michoud, Corey Seehus, Philipp Schönle, Noé Brun, Daniel Taub, Zihe Zhang, Aakanksha Jain, Ivan Furfaro, Outman Akouissi, Rachel Moon, Pascale Meier, Katia Galan, Benjamin Doyle, Michael Tetreault, Sébastien Talbot, Liam E. Browne, Qiuting Huang, Clifford J. Woolf, Stephanie P. Lacour
Nature Biotechnology (2020) (link)
Vagal sensory neurons drive mucous cell metaplasia.
Sebastien Talbot, Benjamin Doyle, Junwei Huang, Jo-Chiao Wang, Maryam Ahmadi, David P. Roberson, Ajay Yekkirala, Simmie L. Foster, Liam E. Browne, Bruce P. Bean, Bruce D. Levy, Clifford J. Woolf
Journal of Allergy and Clinical Immunology 145, 1693-1696.e4 (2020) (link)
Controlling engineered P2X receptors with light.
Benjamin N. Atkinson, Vijay Chudasama, Liam E. Browne
Methods in Molecular Biology (2019) (link)
Optical cuff for optogenetic control of the peripheral nervous system.
Frédéric Michoud, Loic Sottas, Liam E. Browne, Leonie Asboth, Alban Latremoliere, Miyuki Sakuma, Gregoire Courtine, Clifford J. Woolf, Stephanie P. Lacour
Journal of Neural Engineering 15, 015002 (2018) (pdf)
Time-resolved fast mammalian behavior reveals the complexity of protective pain responses.
Liam E. Browne*, Alban Latremoliere, Brendan P. Lehnert, Alyssa Grantham, Catherine Ward, Chloe Alexandre, Michael Costigan, Frédéric Michoud, David P. Roberson, David D. Ginty, Clifford J. Woolf*
Cell Reports 20, 89-98 (2017) *co-corresponding authors (pdf)
Casting light on pain.
Liam E. Browne, Clifford J. Woolf
Nature Biotechnology 32, 240-241 (2014) (link)
Optical control of trimeric P2X receptors and acid-sensing ion channels.
Liam E. Browne, Joao Nunes, Joan A. Sim, Vijay Chudasama, Laricia Bragg, Stephen Caddick, R. Alan North
PNAS 111, 521-526 (2014) (pdf)
Ectodomain movements of ATP-gated ion channel (P2X2 receptor) probed by disulphide locking.
Olga Stelmashenko, Vincent Compan, Liam E. Browne, R. Alan North.
Journal of Biological Chemistry 289, 9909-9917 (2014) (link)
P2X receptor intermediate activation states have altered nucleotide selectivity.
Liam E. Browne, R. Alan North
Journal of Neuroscience 33, 14801-14808 (2013) (pdf)
P2X7 receptor channels allow direct permeation of nanometer-sized dyes.
Liam E. Browne, Vincent Compan, Laricia Bragg, R. Alan North
Journal of Neuroscience 33, 3557-3566 (2013) (pdf)
P2X receptor channels show threefold symmetry in ionic charge selectivity and unitary conductance.
Liam E. Browne, Lishuang Cao, Helen E. Broomhead, Laricia Bragg, William Wilkinson, R. Alan North
Nature Neuroscience 14,17-18 (2011) (pdf) Appears in Faculty of 1000: F1000.com/8819956
Pharmacological properties of the rhesus macaque monkey P2X7 receptor.
Helen J. Bradley, Liam E. Browne, Wei Yang, Lin-Hua Jiang
British Journal of Pharmacology 164(2b), 743-754 (2011)
New structure enlivens interest in P2X receptors.
Liam E. Browne, Lin-Hua Jiang, R. Alan North,
Trends in Pharmacological Sciences 31, 229-237 (2010)
Structural determinants of drugs acting on the Nav1.8 channel.
Liam E. Browne, Frank E. Blaney, Shahnaz P. Yusaf, Jeff J. Clare, Dennis Wray
Journal of Biological Chemistry 284, 10523-10536 (2009)
Functional and pharmacological properties of human and rat Nav1.8 channels.
Liam E. Browne, Jeff J. Clare, Dennis Wray
Neuropharmacology 56, 905-914 (2009)
Photo by Alfons Morales on Unsplash